(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis^[1][2]. In Vivo: (-)-Hydroxycitric acid lactone (1000-3000mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken^[2].