Chemical Name |
Disitertide |
CAS Number |
272105-42-7 |
MDL Number |
MFCD13195512 |
Molecular Formula |
C68H109N17O22S2 |
Molecular Weight |
1580.82 |
Synonyms |
P144 |
Introduction of 272105-42-7 :
Disitertide (P144) is an inhibitor of TGF-β1. In Vitro: Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1]. In Vivo: Treatment with Disitertide (P144) at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.