D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds ^[1]. IC50 & Target: IC50: heptoses precursor^[1] In Vitro: Sedoheptulose 7-phosphate can be converted to ADP-l-glycero-β-d-manno-heptose by SepB, SepL, and SepC, it involves in ADP-sugar in microbial natural product biosynthesis^[1].
SepB is an S-7-P isomerase, SepL involves in the biosynthesis of heptoses of the core region of E. coli LPS, and they catalyze a four-reaction relay converting S-7-P into ADP-d-glycero-β-d-manno-heptose ^[1].
Septacidin and its analogs are potential anticancer and pain-relief agents^[1].
Hygromycin B is an anthelmintic agent practically used in swine and poultry farming^[1].