Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC₅₀ of 0.83 nM^[1]. IC50 & Target: IC50: 0.83 nM (P. falciparum)^[1] In Vitro: Artemisone inhibits 3D7 and K1 P. falciparum, with IC₅₀s of 0.88±0.59 and 1.23±0.64 nM, respectively^[1]. In Vivo: Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED₅₀ of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration^[1].
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS^[1]