Chemical Name |
Felbamate |
CAS Number |
25451-15-4 |
MDL Number |
MFCD00865296 |
Molecular Formula |
C11H14N2O4 |
Molecular Weight |
238.24 |
Synonyms |
W-554;ADD-03055 |
Introduction of 25451-15-4 :
Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). IC50 & Target: NMDA Receptor[1]. In Vitro: Felbamate (W-554) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy[1]. Felbamate (W-554) has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.