Hydroxy desmethyl Bosentan
| Chemical Name | Hydroxy desmethyl Bosentan |
|---|---|
| CAS Number | 253688-62-9 |
| MDL Number | MFCD09840720 |
| Molecular Formula | C26H27N5O7S |
| Molecular Weight | 553.59 |
| Synonyms | Ro 64-1056 |
Introduction of 253688-62-9 :
Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.