Dihydroergocristine (mesylate)
| Chemical Name | Dihydroergocristine (mesylate) |
|---|---|
| CAS Number | 24730-10-7 |
| MDL Number | MFCD00153792 |
| Molecular Formula | C36H45N5O8S |
| Molecular Weight | 707.84 |
| Synonyms | DHEC (mesylate) |
Introduction of 24730-10-7 :
Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1]. In Vitro: Dihydroergocristine (DHEC) (2-20 μM; 24 hours) has an IC50 value of 25 μM for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability[1].
Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.