CP-10 is a PROTAC with highly selective, specific, and remarkable CDK6 degradation (DC₅₀=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6^[1]. IC50 & Target: CDK6^[1] In Vitro: CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC₅₀: 50-80 fold)^[1].
CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC₅₀≈10 nM) and mantle cell lymphoma cells (in Mino, IC₅₀≈8 nM)^[1].