Chemical Name |
Droxidopa |
CAS Number |
23651-95-8 |
MDL Number |
MFCD00004266 |
Molecular Formula |
C9H11NO5 |
Molecular Weight |
213.19 |
Synonyms |
L-DOPS;DOPS;SM5688 |
Introduction of 23651-95-8 :
Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2]. In Vivo: The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow[1].
Droxidopa(L-DOPS) is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. It has no pressor effects in this form. It can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.