8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA)^[1]. IC50 & Target: PKA^[1] In Vitro: 8-Bromo-cAMP is a brominated derivative of cyclic AMP. 8-Bromo-cAMP sodium salt enhances the efficiency of cellular reprogramming. 8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP inhibits proliferation, induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109)^[1].