Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo^[1][2]. In Vitro: Nefopam hydrochloride (Fenazoxine hydrochloride) is a non-opioid, non-steroidal, centrally acting analgesic drug that is derivative of the non-sedative benzoxazocine^[1]. Constitutively elevated β-catenin leads to a delayed and fibrous fracture repair process, and Nefopam inhibits β-catenin mediated signaling during skin wound repair^3].