| Chemical Name |
L-APB |
| CAS Number |
23052-81-5 |
| MDL Number |
MFCD00083244 |
| Molecular Formula |
C4H10NO5P |
| Molecular Weight |
183.10 |
| Synonyms |
L-AP 4 |
Introduction of 23052-81-5 :
L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. IC50 & Target: EC50: 0.13 μM (mGlu4), 0.29 μM (mGlu8), 1.0 μM (mGlu6), 249 μM (mGlu7)[1]. In Vivo: Paw withdrawal threshold in response to application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks. Intrathecal injection of 5 to 30 μg of L-APB significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration[2].
| Purity |
NLT 98% |
| Storage |
at 20ºC 2 years |
*The above information is for reference only.
