Chemical Name |
MPTP (hydrochloride) |
CAS Number |
23007-85-4 |
MDL Number |
MFCD00012790 |
Molecular Formula |
C12H16ClN |
Molecular Weight |
209.72 |
Introduction of 23007-85-4 :
MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease. MPTP hydrochloride, a precusor of MPP+, induces apoptosis[1][2][3]. In Vitro: Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[2]. In Vivo: The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.