3-Phosphoglyceric acid barium is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid barium is involved in alveolar macrophage epigenetic regulation^[1]. In Vitro: 3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed^[1].
3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages^[1].
In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation^[1].