Chemical Name |
FG-2216 |
CAS Number |
223387-75-5 |
MDL Number |
MFCD23136998 |
Molecular Formula |
C12H9ClN2O4 |
Molecular Weight |
280.66 |
Synonyms |
IOX3;YM311 |
Introduction of 223387-75-5 :
FG-2216 (IOX3; YM311) is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo. IC50 value: 3.9 uM [1] Target: PDH inhibitor FG-2216 was orally bioavailable and induced significant and reversible Epo induction in vivo (82- to 309-fold at 60 mg/kg). Chronic oral dosing in male rhesus macaques was well tolerated, significantly increased erythropoiesis, and prevented anemia induced by weekly phlebotomy. Furthermore, modest increases in HbF-containing red cells and reticulocytes were demonstrated by flow cytometry, though significant increases in HbF were not demonstrated by high-pressure liquid chromatography (HPLC) [2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.