Chemical Name |
Zabofloxacin |
CAS Number |
219680-11-2 |
MDL Number |
MFCD18633297 |
Molecular Formula |
C19H20FN5O4 |
Molecular Weight |
401.39 |
Synonyms |
DW-224a (Free base) |
Introduction of 219680-11-2 :
Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1]. IC50 & Target: IC50: bacterial; topoisomerases[1] In Vitro: Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC90: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.