Chemical Name |
PD173212 |
CAS Number |
217171-01-2 |
MDL Number |
MFCD12828777 |
Molecular Formula |
C38H53N3O3 |
Molecular Weight |
599.85 |
Introduction of 217171-01-2 :
PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. IC50 & Target: IC50: 36 nM (VSCC)[1] In Vitro: PD173212 (PD 173212, 300 nM) potently blocks recombinant B-class (N-type) calcium channel currents 78±7.8%, with an IC50 of 74 nM, by whole-cell voltage-clamp techniques. PD 173212 possesses selectivity for non L-type Ca2+ channels versus neuronal Na+, K+, and L-type Ca2+ channels[1]. In Vivo: PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.