Chemical Name |
Fludarabine |
CAS Number |
21679-14-1 |
MDL Number |
MFCD00132942 |
Molecular Formula |
C10H12FN5O4 |
Molecular Weight |
285.23 |
Synonyms |
F-ara-A;NSC 118218 |
Introduction of 21679-14-1 :
Fludarabine (NSC 118218) is a DNA synthesis inhibitor, which also inhibits phosphorylation of STAT1. Fludarabine, a pro-drug, is converted metabolically by dephosphorylation to the antimetabolite, F-ara-A. In Vitro: Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression[4]. In Vivo: Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD[5].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.