Chemical Name |
BMS493 |
CAS Number |
215030-90-3 |
MDL Number |
MFCD17215944 |
Molecular Formula |
C29H24O2 |
Molecular Weight |
404.50 |
Introduction of 215030-90-3 :
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2]. In Vitro: BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation[1]. In Vivo: Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.