Chemical Name |
Oxaprozin |
CAS Number |
21256-18-8 |
MDL Number |
MFCD00215977 |
Molecular Formula |
C18H15NO3 |
Molecular Weight |
293.32 |
Synonyms |
Oxaprozinum;Wy21743 |
Introduction of 21256-18-8 :
Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. IC50 & Target: IC50: 2.2 μM (COX-1), 36 μM (COX-2),NF-κB[1] In Vitro: Oxaprozin induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by 50 μM Oxaprozin. Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα[1]. Oxaprozin dose dependently increase CD40L-treated monocyte apoptosis. 100 μM Oxaprozin induces the strongest proapoptotic effect. 100 μM Oxaprozin significantly increases CD40L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40L-induced Akt and NF-κB (p65) phosphorylation[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.