Compound E
| Chemical Name | Compound E |
|---|---|
| CAS Number | 209986-17-4 |
| MDL Number | MFCD22628908 |
| Molecular Formula | C27H24F2N4O3 |
| Molecular Weight | 490.50 |
Introduction of 209986-17-4 :
Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. IC50 & Target: IC50: 0.24 nM (β-amyloid(40)), 0.37 nM (β-amyloid(42)), 0.24 nM (Notch)[1] In Vitro: Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.