Chemical Name |
Tacrine hydrochloride hydrate |
CAS Number |
206658-92-6 |
MDL Number |
MFCD00150067 |
Molecular Formula |
C13H17ClN2O |
Molecular Weight |
252.74 |
Introduction of 206658-92-6 :
Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. IC50 & Target: IC50: 31 nM (AChE), 25.6 nM (BChE) In Vitro: Tacrine hydrochloride hydrate (12.5 to 37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. The IC50 is 31 nM for snake venom AChE and 25.6 nM for human BChE[1]. In Vivo: Pretreatment with Tacrine hydrochloride hydrate also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride hydrate. Delivery of Tacrine hydrochloride hydrate by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride hydrate treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to Tacrine hydrochloride hydrate- but not saline- treated rats evaluated by conditioned-place preference[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.