Chemical Name |
Tubulysin A |
CAS Number |
205304-86-5 |
MDL Number |
MFCD12912448 |
Molecular Formula |
C43H65N5O10S |
Molecular Weight |
844.07 |
Synonyms |
TubA |
Introduction of 205304-86-5 :
Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. IC50 value: Target: microtubule Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.