Chemical Name |
Tecadenoson |
CAS Number |
204512-90-3 |
MDL Number |
MFCD08690887 |
Molecular Formula |
C14H19N5O5 |
Molecular Weight |
337.33 |
Synonyms |
CVT-510 |
Introduction of 204512-90-3 :
Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist. IC50 & Target: Target: A1 adenosine receptor[1] In Vitro: In the atrial-paced isolated heart, Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41 nM) than to increase coronary conductance (EC50=200 nM). At concentrations of Tecadenoson (40 nM) and diltiazem (1 μM) that causes equal prolongation of S-H interval (∼10 ms), diltiazem, but not Tecadenoson, significantly reduces left ventricular developed pressure (LVP) and markedly increases coronary conductance. Tecadenoson shortens atrial (EC50=73 nM) but not the ventricular monophasic action potentials (MAP)[1]. In Vivo: In atrial-paced anaesthetized guinea-pigs, intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval[1]. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson given at 50 μg/kg causes a significant bradycardia (50% decrease in heart rate at 25 min[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.