| Chemical Name |
Indibulin |
| CAS Number |
204205-90-3 |
| MDL Number |
MFCD05861105 |
| Molecular Formula |
C22H16ClN3O2 |
| Molecular Weight |
389.83 |
| Synonyms |
ZIO 301;D 24851 |
Introduction of 204205-90-3 :
Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1]. IC50 & Target: Tubulin[1] In Vitro: Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM[1].
Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis[1].
Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells[1].
Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells[1].
| Purity |
NLT 98% |
| Storage |
at 20ºC 2 years |
*The above information is for reference only.
