Fmoc-Asp(2-phenylisopropyl ester)-OH
| Chemical Name | Fmoc-Asp(2-phenylisopropyl ester)-OH |
|---|---|
| CAS Number | 200336-86-3 |
| MDL Number | MFCD00237012 |
| Molecular Formula | C28H27NO6 |
| Molecular Weight | 473.52 |
| Synonyms | Fmoc-Asp(OPp)-OH;Fmoc-Asp(O-2-PhiPr)-OH |
An aspartic acid derivative allowing specific side chain deprotection with 1% TFA in dichloromethane. Ocampo et al. applied OPp protection during the synthesis of a peptide-oligonucleotide conjugate and cleaved it with 3% trichloroacetic acid in DCM.
The OPp derivative is far less prone towards base-catalyzed aspartimide formation than the OAll, OBzl, or ODmab esters, its stability comes close to the stability of the OtBu ester.
The OPp derivative is far less prone towards base-catalyzed aspartimide formation than the OAll, OBzl, or ODmab esters, its stability comes close to the stability of the OtBu ester.
| Purity | NLT 98% |
|---|---|
| Storage | -20 ± 5 ºC |
*The above information is for reference only.