Chemical Name |
MJ33-OH |
CAS Number |
199106-13-3 |
MDL Number |
MFCD03787978 |
Molecular Formula |
C22H43F3LiO6P |
Molecular Weight |
498.48 |
Introduction of 199106-13-3 :
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6[1]. In Vivo: MJ33 (0.5 μM/kg ; by tail vein, at 24 h before MCAO) significantly blocks the increase IL-1β, IL-17 and IL-23 in rats stimulated by Prdx6 siRNA treatment[2].
Compared with the Prdx6 siRNA group, combined exposure to Prdx6 siRNA and MJ33 significantly downregulates the mRNA and protein expression of NF-κB, iNOS and COX-2[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.