Chemical Name |
Bavachinin |
CAS Number |
19879-30-2 |
MDL Number |
MFCD06858396 |
Molecular Formula |
C21H22O4 |
Molecular Weight |
338.40 |
Synonyms |
7-O-Methylbavachin;Bavachinin A |
Introduction of 19879-30-2 :
Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity. IC50 value: Target: in vitro: Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated Aβ42-induced toxicity in a SH-SY5Y cell model [1]. Bavachinin, has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α [2]. in vivo: significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model [3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.