Chemical Name |
Parecoxib (Sodium) |
CAS Number |
198470-85-8 |
MDL Number |
MFCD04972608 |
Molecular Formula |
C19H17N2NaO4S |
Molecular Weight |
392.40 |
Synonyms |
SC 69124A |
Introduction of 198470-85-8 :
Parecoxib Sodium (SC 69124A) is a potent and selective COX-2 inhibitor. IC50 value: Target: COX-2 in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1]. in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.