(S,R,S)-AHPC-Me (hydrochloride)
1948273-03-7
DY536475
C23H32N4O3S
444.59
VHL ligand 2 (hydrochloride);E3 ligase Ligand 1
| Chemical Name | (S,R,S)-AHPC-Me (hydrochloride) |
|---|---|
| CAS Number | 1948273-03-7 |
| Molecular Formula | C23H32N4O3S |
| Molecular Weight | 444.59 |
| Synonyms | VHL ligand 2 (hydrochloride);E3 ligase Ligand 1 |
Introduction of 1948273-03-7 :
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2]. IC50 & Target: Ligand for E3 Ligase[1]
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.