Chemical Name |
Capromorelin (Tartrate) |
CAS Number |
193273-69-7 |
MDL Number |
MFCD22572727 |
Molecular Formula |
C32H41N5O9 |
Molecular Weight |
639.70 |
Synonyms |
CP 424391-18 |
Introduction of 193273-69-7 :
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a. IC50 & Target: Ki: 7 nM (hGHS-R1a)[2] In Vitro: Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM[2]. In Vivo: Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group[1]. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%][2]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.