Chemical Name |
ZM323881 |
CAS Number |
193001-14-8 |
MDL Number |
MFCD09037564 |
Molecular Formula |
C22H18FN3O2 |
Molecular Weight |
375.40 |
Introduction of 193001-14-8 :
ZM323881 is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. IC50 & Target: IC50: 2 nM (VEGFR2)[1] In Vitro: ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC50>50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC50=8 nM) and VEGFR2 tyrosine phosphorylation[1]. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.