Pralnacasan
| Chemical Name | Pralnacasan |
|---|---|
| CAS Number | 192755-52-5 |
| MDL Number | MFCD18381953 |
| Molecular Formula | C26H29N5O7 |
| Molecular Weight | 523.54 |
| Synonyms | VX-740;HMR 3480 |
Introduction of 192755-52-5 :
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment[1][2]. In Vivo: Pralnacasan (0 -50 mg/kg; oral gavage; twice a day; for 6 weeks; female Balb/c mice) treatment reduces joint damage. Pralnacasan treatment does not appear to affect the weight of the animals[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.