Chemical Name |
PD-166866 |
CAS Number |
192705-79-6 |
MDL Number |
MFCD12922514 |
Molecular Formula |
C20H24N6O3 |
Molecular Weight |
396.44 |
Introduction of 192705-79-6 :
PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM. IC50 & Target: IC50: 52.4 nM (hFGFR1 tyrosine kinase)[1] In Vitro: PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with an IC50 value of 52.4 nM and is characterized as an ATP competitive inhibitor of the FGFR-1. PD 166866 is a potent inhibitor of FGFR autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and in L6 cells overexpressing the human FGFR-1 tyrosine kinase. PD 166866 also inhibits bFGF-induced tyrosine phosphorylation of the 44- and 42-kDa (ERK 1/2) mitogen-activated protein kinase isoforms in L6 cells. Daily exposure of PD 166866 to L6 cells at concentrations from 1 to 100 nM results in a concentration-related inhibition of bFGF-stimulated cell growth for 8 consecutive days with an IC50 value of 24 nM[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.