Aristeromycin
| Chemical Name | Aristeromycin |
|---|---|
| CAS Number | 19186-33-5 |
| MDL Number | MFCD00078836 |
| Molecular Formula | C11H15N5O3 |
| Molecular Weight | 265.27 |
Introduction of 19186-33-5 :
Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2]. IC50 & Target: S-adenosylhomocysteine hydrolase[1] In Vitro: The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1].
Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1].
At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.