Chemical Name |
Chebulinic acid |
CAS Number |
18942-26-2 |
MDL Number |
MFCD06656295 |
Molecular Formula |
C41H32O27 |
Molecular Weight |
956.68 |
Introduction of 18942-26-2 :
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. IC50 & Target: target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3] In Vitro: In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.