Chemical Name |
KU14R |
CAS Number |
189224-48-4 |
MDL Number |
MFCD01861185 |
Molecular Formula |
C13H14N2O |
Molecular Weight |
214.26 |
Introduction of 189224-48-4 :
KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. IC50 Value: Target: Insulin Receptor A new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.