Chemical Name |
PNU-142633 |
CAS Number |
187665-65-2 |
MDL Number |
MFCD10687093 |
Molecular Formula |
C24H30N4O3 |
Molecular Weight |
422.52 |
Introduction of 187665-65-2 :
PNU-142633 is a high affinity, selective and orally active 5-HT1D receptor agonist with Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively. PNU-142633 has anti-migraine efficacy[1][2]. In Vitro: The intrinsic activity of PNU-142633 at the human 5-HT1D receptor is determined to be 70% that of 5-HT in a cytosensor cell-based assay compared with 84% for that of Sumatriptan[1]. In Vivo: PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation. And PNU-142633 fails to alter resistance in these vascular beds[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.