Chemical Name |
TAPI-2 |
CAS Number |
187034-31-7 |
MDL Number |
MFCD22581509 |
Molecular Formula |
C19H37N5O5 |
Molecular Weight |
415.53 |
Synonyms |
TNF Protease Inhibitor 2 |
Introduction of 187034-31-7 :
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP. IC50 & Target: IC50: 20±10 μM (MMP)[1] Ki: 1.5±0.27 nM (MMPs)[1] In Vitro: The hydroxamate-based metalloprotease inhibitor TAPI-2 bounds to hmeprin with inhibition constants IC50 20±10 μM for hmeprin β subunit and 1.5±0.27 nM for hmeprin α subunit. Generally, hmeprin α is inhibited more strongly than the β subunit[1]. Without affecting ADAM17 expression, TAPI-2 dramatically decreases the protein levels of NICD and its downstream target HES-1 in both HCP-1 and HT29 cells. Moreover, treating cells with TAPI-2 significantly decreases the CSC phenotype by -50% in both CRC cell lines. The dose-dependent effects of TAPI-2 on the sphere formation and protein levels of NICD and HES-1 confirm that the concentration used (20 μM) is within the effective dose range of TAPI-2 (5–40 μM)[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.