Chemical Name |
Zibotentan |
CAS Number |
186497-07-4 |
MDL Number |
MFCD09955343 |
Molecular Formula |
C19H16N6O4S |
Molecular Weight |
424.43 |
Synonyms |
ZD4054 |
Introduction of 186497-07-4 :
Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). IC50 value: 21 nM Target: ETA receptor Zibotentan is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.