Chemical Name |
Carabersat |
CAS Number |
184653-84-7 |
MDL Number |
MFCD00944470 |
Molecular Formula |
C20H20FNO4 |
Molecular Weight |
357.38 |
Introduction of 184653-84-7 :
Carabersat is a potent anticonvulsant agent. In Vitro: [3H]Carabersat ([3H]SB 204269) binds to rat forebrain membranes with moderate affinity (Kd 40 nM) and pKi values of 7.3[1]. Carabersat is able to bind to mouse forebrain membranes, and the binding is saturable and stereospecific, with a Kd of 53 nM. The labelled [3H]Carabersat produces a Kd of 32 nM[2]. Carabersat (SB-204269, 1-100 μM) has no effect on Na+ current in cultured hippocampal neurones. Carabersat also shows no effect on action potential discharges evoked by elevating external K+[3]. Carabersat (SB-204269) is structurally-related to the benzopyran ATP-sensitive potassium channel (KATP) opener, cromakalim, but has opposite stereochemistry, and the mechanism of action of Carabersat is not thought to involve KATP[4]. In Vivo: Carabersat (5b) significantly elevates anticonvulsant activity in mice[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.