CAS No. 1841-19-6, Fluspirilene

Fluspirilene

NLT 98%
1841-19-6
DY534376
C29H31F2N3O
475.57
R 6218;Redeptin

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Chemical Name Fluspirilene
CAS Number 1841-19-6
MDL Number MFCD00055137
Molecular Formula C29H31F2N3O
Molecular Weight 475.57
Synonyms R 6218;Redeptin
Introduction of 1841-19-6 :

Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic drug used for schizophrenia. IC50 & Target: IC50: 0.03 μM (L-type calcium channel)[1] In Vitro: Fluspirilene, at concentrations which non-competitively modify dihydropyridine binding, selectively antagonizes the effects of calcium-channel activators[1]. Fluspirilene decreases the viability and suppresses sphere-forming of glioma stem cell lines in a dose-dependent manner. Fluspirilene demonstrates the inhibition of proliferation of T98, U87 and all GSC lines at 1.25, 2.5, and 5 μM, while it inhibits the proliferation of U251 and SNB19 at 2.5 and 5 μM[2]. In Vivo: Mice treated with fluspirilene shows a remarkable reduction of the tumor size. Fluspirilene significantly prolongs survival of the TGS04 mouse model[2].

Purity NLT 98%
Storage at 20ºC 2 years
*The above information is for reference only.

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