Chemical Name |
Abaperidone |
CAS Number |
183849-43-6 |
MDL Number |
MFCD00951995 |
Molecular Formula |
C25H25FN2O5 |
Molecular Weight |
452.47 |
Introduction of 183849-43-6 :
Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. IC50 & Target: IC50: 17 nM (D2 receptor), 6.2 nM (5-HT2A receptor)[1] In Vitro: Abaperidone possesses good affinity for dopamine D2 receptors, together with a greater affinity for 5-HT2 receptors with IC50 of 17 and 6.2 nM, reaspectively[1]. In Vivo: The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.