Chemical Name |
Gemcabene |
CAS Number |
183293-82-5 |
MDL Number |
MFCD00951832 |
Molecular Formula |
C16H30O5 |
Molecular Weight |
302.41 |
Synonyms |
PD-72953 |
Introduction of 183293-82-5 :
Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3]. In Vitro: Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.