Chemical Name |
Cabazitaxel |
CAS Number |
183133-96-2 |
MDL Number |
MFCD18827611 |
Molecular Formula |
C45H57NO14 |
Molecular Weight |
835.93 |
Synonyms |
XRP6258;RPR-116258A;taxoid XRP6258 |
Introduction of 183133-96-2 :
Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. In Vitro: The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%[1]. In Vivo: Cabazitaxel (10 mg/kg, i.v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.