Chemical Name |
Netropsin (dihydrochloride) |
CAS Number |
18133-22-7 |
MDL Number |
MFCD06804579 |
Molecular Formula |
C18H30Cl2N10O4 |
Molecular Weight |
521.40 |
Introduction of 18133-22-7 :
Netropsin (dihydrochloride) is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei[1]. Netropsin (dihydrochloride) has potential antibiotic and antiviral properties by binding to dsDNA in a non-intercalative manner, it improves survival from murine endotoxaemia by attenuating NOS2 induction through interference with HMGA1 DNA binding to the core NOS2 promoter[2]. Netropsin (dihydrochloride) in solutions of DNA has radioprotective ability against radiation-induced damage due to its high binding affinity and high structural stabilization, hydroxyl radical (OH*) generated by ionizing radiation cannot radiolyse the netropsin-DNA complex[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.