Chemical Name |
LLY-507 |
CAS Number |
1793053-37-8 |
Molecular Formula |
C36H42N6O |
Molecular Weight |
574.76 |
Introduction of 1793053-37-8 :
LLY-507 is a potent inhibitor of SMYD2 with IC50 < 15 nM, is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets. IC50 value: < 15 nM Target: SMYD2 in vitro: LLY-507 shows the inhibitor binding in the substrate peptide binding pocket. LLY-507 is active in cells as measured by reduction of SMYD2-induced monomethylation of p53 Lys370 at submicromolar concentrations. LLY-507 inhibits the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.