Chemical Name |
PHCCC |
CAS Number |
179068-02-1 |
MDL Number |
MFCD00947860 |
Molecular Formula |
C17H14N2O3 |
Molecular Weight |
294.30 |
Introduction of 179068-02-1 :
PHCCC is a Group I metabotropic glutamate receptor antagonist with EC50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8. target: a Group I metabotropic glutamate receptor antagonist EC 50: 6 uM In vitro: PHCCC potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. In vivo: 1, PHCCC produced antiparkinsonian efficacy in the reserpinized rat model means a significant level of glutamate is available for the activation of the therapeutically relevant mGluR4. 2, The reference for animal administration is 10 mg/kg.(i.p) 3,PHCCC augmentes in vivo genetic and pharmacological models of absence seizures in rats.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.