Chemical Name |
TAS-103 (dihydrochloride) |
CAS Number |
174634-09-4 |
MDL Number |
MFCD00943251 |
Molecular Formula |
C20H21Cl2N3O2 |
Molecular Weight |
406.31 |
Synonyms |
BMS-247615 dihydrochloride |
Introduction of 174634-09-4 :
TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. IC50 & Target: Topoisomerase I/II[1] In Vitro: TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability of HeLa cells, with an IC50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation[3]. In Vivo: TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.