Chemical Name |
Edotecarin |
CAS Number |
174402-32-5 |
MDL Number |
MFCD00946605 |
Molecular Formula |
C29H28N4O11 |
Molecular Weight |
608.55 |
Synonyms |
J 107088; PF 804950 |
Introduction of 174402-32-5 :
Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM. IC50 & Target: IC50: 50 nM (topoisomerase I)[1] In Vitro: In the presence of human colon cancer cells labeled with 3Hthymidine, edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner[1]. In Vivo: Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect[1]. Edotecarin results in tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Combination treatment of edotecarin plus irinotecan improves antitumor activity in vivo compared with either agent alone[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.